BOTTOM LINE: Haven't tried and don't expect to.
Prolotherapy, also referred to as proliferation therapy or regenerative injection therapy, involves injecting an irritant, usually a sugar solution—dextrose—into a joint, tendon, or ligament to stimulate healing (connective tissue growth) and reduce pain. Prolotherapy focuses on patients with joint pain or laxity in ligaments or tendons. It does not claim to reduce myofascial tightness, which is what I’m looking for in a treatment for myofascial pain syndrome.
I’ve spoken with people who had positive experiences with prolotherapy in treating their pain, but not those with myofascial neck problems like mine. I also know people who have had very bad experiences with it, especially when their problems weren’t tendon- or ligament-related.
Platelet Rich Plasma (PRP) therapy is another type of prolotherapy where a person’s platelet-concentrated blood plasma is injected into an injured and painful site (e.g., joint) to help initiate repair of tendons or ligaments and to intensify the body’s healing process.
Since my myofascial pain syndrome isn’t related to joint, ligament, or tendon pain, but rather oxygen deprivation of soft tissue (fascia) surrounding my muscles, and evidence hasn’t shown efficacy of prolotherapy for myofasical pain, I don’t think injecting an irritant or platelet-rich plasma into my body will help me. Treatments I’ve found to work best are those that help reduce fascial tightness such as John F. Barnes Myofascial Release therapy (JFB-MFR), heat (e.g., heat patches, hot tub), and/or moderate exercise such as walking/jogging or biking.
Described below is one of the many approaches I've tried or considered trying for healing my chronic myofascial pain: